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Giri, Tapan Kumar
- β-Cyclodextrin and Its Derivatives Based Drug Delivery
Authors
1 Rungta College of Pharmaceutical Sciences and Research, Kohka Road, Kurud, Bhilai-491024, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 6 (2010), Pagination: 361-369Abstract
Cyclodextrins were first described by Villiers in 1891. Schrodinger laid the foundation of the cyclodextrin chemistry in 1903 - 1911 and identified both a and β cyclodextrin. In the 1930 s, Freudenberg identified γ-cyclodextrin and suggested that larger cyclodextrins could exist. Cyclodextrins are cyclic oligosaccharides which have recently been recognized as useful pharmaceutical excipients. The molecular structure of these glucose derivatives, which approximates a truncated cone or torus, generates a hydrophilic exterior surface and a nonpolar cavity interior. As such, cyclodextrins can interact with appropriately sized molecules to result in the formation of inclusion complexes. These non covalent complexes offer a variety of physico-chemical advantages over the unmanipulated drugs including the possibility for increased water solubility and solution stability. The purpose of this review is to discuss and summarize some of the interesting findings and applications of β-cyclodextrins and its derivatives in different areas of drug delivery, particularly in protein and peptide drug delivery and gene delivery. The article highlights important cyclodextrin applications in the design of various novel delivery systems like liposome's, microspheres and nanoparticles.Keywords
Complexation, Solubility, Colon Specific, Protein And Peptide, Gene Delivery.- Orodispersible Tablets: An Overview of Tastemasking and Evaluation Techniques
Authors
1 Rungta College of Pharmaceutical Sciences and Research, Kohka Road, Kurud, Bhilai-491024, IN
2 Calcutta Institute of Pharmaceutical Technology and Allied Health Sciences, Uluberia, Howrah-711316, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 3 (2010), Pagination: 225-232Abstract
Over a decade, the demand for development of orodispersible tablets (ODTs) has enormously increased as it has significant impact on the patient compliance. Orodispersible tablets offer an advantage for populations who have difficulty in swallowing. Upon introduction into the mouth, these tablets dissolve or disperse in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. Many orally administered active pharmaceutical ingredients elicit bitter taste. Palatability is an extremely important factor in ensuring the likelihood that the recipients will intake the pharmaceuticals. After ODTs dissolve/disperse in the saliva, the active pharmaceutical ingredient in ODTs remains in the oral cavity until it is swallowed. Therefore, taste masking is critically important in the formulation for maximal patient acceptability. This article attempts to present a detailed review regarding methodologies and approaches of taste masking of active pharmaceutical ingredients and also various evaluation techniques.Keywords
Disintegration Test, Tensile Strength, Microencapsulation, Inclusion Complex.- A Review on Pharmacological Profile for Phytomedicine Known as Linn
Authors
1 Rungta College of Pharmaceutical Sciences and Research, Bhilai (C.G), IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 3 (2011), Pagination: 103-107Abstract
Application indigenous natural products has been alternative way to replace synthetic medicine Gloriosa superba is a well known ethnomedicinal plant which is used in Ayurveda. Photochemical studies of G. superba shows presence of colchicin, b-siltosterol, long chain fatty acids, b and glumiccolchicines, 2-hydroxy-6-methoxy benzoic, luterlin, N-formyl-deacetyl colchicines and new colchicine glycoside, 3-O-demethylcolchicine-3-Oalpha- D- glucopyranoside. FDA-approved use of Colchicine is to treat gout (it is one of the active ingredients of anti-gout tablets marketed by Merck&Co.). It is also used as an anticancer, antimicrobial, antifungal, anticoagulant, antilipoxygenase agent and antidote in snake bite. However, ingestion of all parts of the plant is extremely poisonous and can be fatal. The commonest clinical presentation of poisoning is severe gastroenteritis with nausea, vomiting, diarrhoea with b leading to dehydration, hypovolaemic shock and acute renal failure. Gloriosa superba usually multiply by corm and seeds but due to low germination capability it restricts for the regeneration. Therefore, in order to safeguard and preserve this important plant biotechnological approachs would be very useful. Micropropagation of Gloriosa superba meets ever increasing demands for colchicine. The availability from both wild and cultivated sources make the plant of Gloriosa superba a potential source of Colchicine in India.